After years of research on a multi-center trial from the NIH Helping to End Addiction Long-Term® Initiative (HEAL), Lori Devlin et al recently published results comparing Eat, Sleep, Console (ESC) pharmacologic treatment based upon symptoms and Finnegan-scheduled opioid taper with their OPTimize NOW trial. Key Findings Read the full study in JAMA. Expert Perspectives The…
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Author: John Konsin, Principal Founder, Prapela, Inc. | April 23, 2026 Prapela is pleased to make our Clinical Evidence Summary available to clinicians, NICU leaders, and care teams managing NAS/NOWS. This peer-reviewed resource covers: ✅ The pivotal study, Bloch-Salisbury et al. RCT (JAMA Pediatrics, 2023, n=181).✅ The Singh et al. multicenter RCT (Pediatric Research, 2025)…
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In 2023, a multicenter trial involving 26 units using “Eat, Sleep, and Console” (ESC) versus traditional care for babies exposed prenatally to opioids found the effectiveness of the ESC approach in reducing the length of stay in the hospital, decreased medication use, and enhanced family involvement in managing Neonatal Opioid Withdrawal Syndrome (NOWS). Understanding Neonatal…
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